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Brazilian berries may hold the key to cancer treatment

Come Come, a polyphenol-rich Amazon berry, may help fight cancer with castaragin, a polyphenol that acts as a prebiotic.

Polyphenols are “organic compounds that are abundant in plants and [which] In recent decades, it has become a new area of ​​interest in nutrition. “

Recent reviews Note “Increased research shows that polyphenol consumption can play an important role in health through the regulation of metabolism, body weight, chronic disease, and cell proliferation.”

Researchers in Canada have discovered that castaragin, a polyphenol from Camcamberry, Brazil, helps increase the effectiveness of immunotherapy in mice by modifying the microbial flora.

“Berry come come rich in polyphenols (CC, Myrciaria dubia) With a mouse, “the researchers write. “The composition of gut microbiota has changed, converting it to antitumor activity and a more potent anti-PD-1 response.” Programmed cell death protein 1 (PD-1) is an “inhibitory receptor expressed by all T cells during activation. During various physiological responses, including acute and chronic infections, cancer and autoimmunity, and in immune constancy. , Regulates T cell effector function. “

Simply put, the Amazon fruit come come can help fight cancer.Researcher to write Cancer detection A journal under the leadership of Dr. Bertland Rooty, a professor at the University of Montreal School of Medicine, points out that compounds from Camcam may have a positive impact on immunotherapy.

“In this study, in collaboration with colleagues at Universite Laval and McGill University, castaragin, a prebiotic polyphenol, modifies the gut microbiota and provides immunotherapy for cancers that are resistant to this type of treatment. It has been proven to improve the response. ” Rooty.

“Our results pave the way for clinical trials using castaragin as a complement to a drug called an immune checkpoint inhibitor in cancer patients,” said Routy’s PhD student and lead author of the study. Meriem Messaoudene, who is, adds.

Immune Checkpoint Inhibitor (ICI) “Appeared [in the past decade] As an anticancer drug that can better correct the natural history of a wide range of malignant tumors such as melanoma, renal cell carcinoma, non-small cell lung cancer (NSCLC), bladder cancer, and Hodgkin lymphoma. “

Patients are moved by the ICI, which activates the immune system and kills cancer cells, but according to news releases, only a few patients have a long-term response to “curative-like” immunotherapy. There are only a few.

Researchers such as Routy are looking for new treatments in hopes of transforming unhealthy microbiota into healthy microbiota in order to strengthen the immune system.

One of the ideas Routy had was Prebiotics, “Can nourish the gut microbiota, their degradation products are short-chain fatty acids, released into the blood circulation, and as a result, affect not only the gastrointestinal tract but also other distant organs. . “

“To assess the beneficial effects of castaragin, we orally administered prebiotics to mice that received a fecal transplant from ICI-tolerant patients,” he says. “Castaragin has been found to bind to beneficial gut bacteria. Ruminococcus bromies, And promotes anti-cancer response. “

The researchers’ findings will soon be tested in 45 individuals suffering from lung cancer or melanoma. This will be the first clinical trial to combine polyphenols from Brazilian come come berries, castaragin, and ICI.

“As part of that, the Weston Family Foundation has funded up to $ 1 million over three years. Brain Health 2021: Lifestyle Approach and Contribution of Microbiota Program “, news release notes.

Source: TRT World and distributors

https://www.trtworld.com/life/a-brazilian-berry-may-hold-the-key-to-cancer-treatment-54429?utm_source=other&utm_medium=rss Brazilian berries may hold the key to cancer treatment

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