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New insights into inflammation that promotes heart disease: research

Boston: A new study found that bone marrow factors increase the production of white blood cells that cause inflammation in cardiovascular disease.

This study was published in the “Nature Cardiovascular Research Journal”.

“Patients with heart disease have higher numbers of leukocytes,” said Matthias Narendorf, MD, a researcher at MGH’s Center for Systems Biology and a senior author of radiology at Harvard Medical School.

“Many of these cells are found in plaques (accumulation of fat, cholesterol, and other substances in blood vessels) that arrive after being born in the bone marrow and traveling through the bloodstream, but increased bone marrow excretion. It’s not clear what leads to, “added Narendorf.

Through experiments conducted in human bone marrow and mice, Nahrendorf et al. Discovered that hypertension, atherosclerosis, and the development of a heart attack can each cause changes in the number of blood vessels in the bone marrow. These features of cardiovascular disease also altered the structure and function of bone marrow vessels and affected the release of factors that regulate leukocyte production and migration.

“As a result, more white blood cells are available in the body, and this increase, called leukocytosis, promotes inflammation everywhere, including the arteries and heart,” Narendorf explained.

“This study will help us find out how to reduce white blood cell production to normal levels, thereby cooling inflamed plaques anywhere in the body,” Narendorf added.

Co-authors include MGH’s David Rohde, MD, Katrien Vandoorne, PhD and others.

Funding for the study was provided by the National Heart, Lung, and Blood Institute grant P01HL142494.

“This study provides strong evidence that cardiovascular disease affects the myeloid vascular system and, as a result, the activity of blood stem cells,” said the Department of Cardiovascular Science, National Institute of Cardiopulmonary Blood Research. Said Dr. Michel Olive, Program Officer of. National Institute of Health.

“This study sheds new light on the important role played by the vascular bone marrow niche and how inflammation develops, which may lead to new targets and treatments for heart disease, the leading cause of death. “She concludes.

https://www.siasat.com/new-insights-on-inflammation-promoting-heart-disease-study-2248036/ New insights into inflammation that promotes heart disease: research

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