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Scientists have probed bats’ immune responses to live infections for the first time

Washington [US], November 29 (ANI): Scientists at Duke-NUS Medical School and colleagues in Singapore sequenced the reaction of colony-reared cave honey bats (Eonycteris spelaea) to viral infection at single-cell resolution. . The findings, published in the journal Immunity, contribute to insights into bat immunity that can be used to protect human health.

Bats carry many types of viruses. Infection with a deadly virus does not cause any noticeable signs or symptoms of illness.

“By understanding how the bat immune response protects bats from infection, we hope to provide clues to better combating viral infections,” said Duke-NUS’s Emerging Infectious Diseases (EID). Researcher Dr. Akshamal Gamage explained. ) co-first author of the program and study.

“Knowing how to better fight viral infections could help develop treatments that can help us become more bat-like,” said Wharton Chan, an MD-PhD candidate at Duke University. NUS is also the co-first author of .

In this study, we investigated the immune response of bats to Malacca virus, a double-stranded RNA virus that utilizes bats as a natural host. The virus also causes mild respiratory illness in humans.

The team used single-cell transcriptome sequencing to study the lung’s immune response to infection at the cellular level, identifying different types of immune cells in bats, some of which are similar to others, including humans. It has been shown that they are different from mammalian immune cells. We do this in response to such viral infections.

They found that a type of white blood cell called neutrophils showed very high expression of a gene called IDO1, which is known to play a role in mediating immunosuppression in humans. Scientists believe that IDO1 expression in cave honey bats may play an important role in reducing post-infection inflammation.

Feng Zhu, Ph.D., EID Program Research Fellow and co-first author of the study, said: “It consumes viral particles and teaches T cells how to recognize the virus. Bats have been shown to clearly activate immune responses after infection, despite exhibiting few apparent symptoms or pathology.” This observation is intriguing because we know that there is a lot of activity.” T cells and natural killer cells (named for their ability to kill tumor cells and virus-infected cells) are widely activated to respond to infection. Contained in cave nectar bats.

“This is the first study to detail the immune response of bats to in vivo infection at the single-cell transcriptome level,” said Professor Linfa Wang, senior author of the study in the EID Program. “We believe our study will serve as an important guide to inform further investigations to uncover the amazing biology of bats.In the future, in addition to research on viral disease resistance, bats will be used as long-lived mammals. We want to uncover clues to longevity from these bats.Learn how these honey-eating bats can survive on a high-sugar diet of nectar without becoming diabetic.”

http://www.singaporenews.net/news/273135861/scientists-reveal-first-close-up-look-at-bats-immune-response-to-live-infection Scientists have probed bats’ immune responses to live infections for the first time

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