Berlin: New studies show that intensive lifestyle interventions help people with prediabetes delay or prevent type 2 diabetes.
The results of the study are published in the journal “Diabetes”.
In particular, pre-diabetic individuals at highest risk benefited from intensive lifestyle interventions. Studies by the German Diabetes Research Center (DZD) were conducted at eight centers throughout Germany.
More exercise and healthy eating behavior help many people with prediabetes normalize their blood sugar levels and avoid the development of type 2 diabetes. However, not everyone will benefit from traditional lifestyle interventions (LI). Recent studies show that prediabetes already has different subtypes with different risk profiles.
Therefore, researchers at the German Center for Diabetes Research (DZD) have conducted multicenter randomized controlled trials to determine whether prediabetes and high-risk people will benefit from enhanced interventions, and whether low-risk people will benefit from traditional LI. I investigated how it would be affected in comparison with. Lifestyle does not change.
LI lasted 12 months in each case and had an additional 2 years of follow-up. A total of 1,105 pre-diabetic patients were investigated at various German research sites and assigned to high-risk or low-risk phenotypes based on insulin secretion, insulin sensitivity, and liver fat content. 82% of the participants completed the survey.
High-risk people (these people either produce too little insulin or suffer from insulin-resistant fatty liver) are more focused on the Diabetes Prevention Program (DPP) or twice the amount of exercise required. Following the intervention, they were randomly assigned to receive traditional LI.
The results showed that more exercise, or more intensive LI, helps high-risk people improve blood sugar and cardiac metabolism levels and reduce liver fat content to within normal limits. .. Traditional LI is not very effective.
Low-risk participants completed traditional LI or enrolled in a control group with only one brief consultation.
“Three years later, participants in traditional LI were more likely to normalize glucose tolerance than participants in the control group,” said Hans Ulrich Herring, a professor at the German Diabetes Research Center, at the end of the study. The author said.
There was little difference in insulin sensitivity and secretion, liver fat content, and cardiac metabolic risk.
“Our findings show that individual LIs based on risk phenotype are beneficial in preventing diabetes,” said Helmholtz-Munich Diabetes Institute and Research Leader at the University of Tubingen (IDM). Professor Andreas Fritsche said. Summarizes the results of diabetes, endocrinology and nephrology (Director: Professor Andreas Berkenfeld) at the University of Tubingen Hospital. “For successful prevention, we need to focus on identifying high-risk patients in the future and providing them with enhanced lifestyle interventions.”
https://www.siasat.com/study-finds-people-with-high-risk-prediabetes-benefit-from-lifestyle-intervention-2246237/ Studies show that high-risk prediabetes benefit from lifestyle interventions