The first female reported that HIV had healed after a stem cell transplant
Another breakthrough in the fight against HIV sees a third person cured of the virus, along with activists who want the world to be one step closer to eradicating the disease globally.
The case is part of a large US-sponsored study led by Dr. Yvonne Bryson of the University of California, Los Angeles and Dr. Deborah Perseau of Johns Hopkins University in Baltimore. (AP)
Researchers in the United States report that they may have treated a woman infected with HIV for the first time.
Leukemia patients in the United States have become the first and third HIV-cured women to date after receiving a stem cell transplant from a donor who is naturally resistant to the virus that causes AIDS.
Cases of mixed-breed middle-aged women presented at a conference on retroviruses and opportunistic infections in Denver also include cord blood, a new approach that may make treatment available to more people. This is the first case.
Since receiving cord blood to treat acute myeloid leukemia (a cancer that develops in the hematopoietic cells of the bone marrow), women have been in remission for 14 months, are virus-free, and do not require intensive HIV treatment, such as: Antiretroviral therapy.
The previous two cases occurred in men (one Caucasian and one Latino) who received adult stem cells, which are more frequently used in bone marrow transplants.
“This is currently the third report of treatment in this situation and the first report of a woman living with HIV,” Sharon Lewin, Deputy President of the International AIDS Society, said in a statement.
read more: Hope for HIV patients: Infected women will not be infected with the virus themselves
US-sponsored research
The case is part of a large US-sponsored study led by Dr. Yvonne Bryson of the University of California, Los Angeles (UCLA) and Dr. Deborah Perseau of Johns Hopkins University in Baltimore.
It aims to track 25 HIV-infected individuals who have been transplanted with stem cells from cord blood for the treatment of cancer and other serious conditions.
Patients under study first receive chemotherapy to kill cancerous immune cells. Doctors then transplant stem cells from individuals with specific genetic mutations that lack the receptors that the virus uses to infect cells.
Scientists believe that these individuals develop an immune system that is resistant to HIV.
Bone marrow transplantation is not a viable strategy for treating most people living with HIV, Lewin said. However, the report “confirms that HIV treatments are possible and will further enhance the use of gene therapy as a viable strategy for HIV treatments,” she said.
This study suggests that transplantation of HIV-resistant cells is a key factor in success.
Previously, scientists believed that the side effects of a common stem cell transplant, called graft-versus-host disease, in which the donor’s immune system attacks the recipient’s immune system, play a role in possible treatments. rice field.
“In summary, all three of these cases of post-stem cell transplantation help make fun of the various elements of transplantation that were the absolute key to treatment,” Lewin said.
read more: The world’s first HIV-cured patient dies of cancer
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