London — Researchers have rejuvenated the skin cells of a 53-year-old woman, equivalent to a 23-year-old woman.
Cambridge scientists believe that the same can be done with other tissues in the body.
The ultimate goal is to develop treatments for age-related diseases such as diabetes, heart disease and neuropathy.
This technique is based on the technique used to create cloned sheep dollies over 25 years ago.
Professor Wolf Reik, team leader at the Babraham Institute in Cambridge, told BBC News that he hopes the technology can ultimately be used to keep people healthier and longer as they get older.
“We have dreamed of this kind of thing. Many common illnesses get worse with age, and it’s very exciting to think about helping people in this way,” he said.
Professor Like emphasized that the research published in the journal eLife was in the very early stages. He said there were some scientific problems that had to be overcome before it moved from his lab to the clinic. But he said that demonstrating for the first time that cell rejuvenation is possible is an important step forward.
The origin of this technology comes from the 1990s when researchers at the Rosslin Institute in the suburbs of Edinburgh developed a method for converting adult mammary gland cells from sheep into embryos. That led to the creation of the cloned sheep Dolly.
The purpose of the Roslin team was not to clone sheep or actually humans, but to use this technique to create so-called human embryonic stem cells. They expected that they could grow into specific tissues such as muscle, cartilage, and nerve cells to replace worn body parts.
Dolly’s method was simplified in 2006 by Professor Shinya Yamanaka (at that time, Kyoto University). A new method called IPS added chemicals to adult cells for about 50 days. This resulted in a genetic change that turned adult cells into stem cells.
With both dolly and IPS technologies, the stem cells created need to re-grow into the cells and tissues that the patient needs. This has proven difficult, and despite decades of effort, the use of stem cells to treat the disease is currently very limited.
Professor Reik’s team used IPS technology on 53-year-old skin cells. However, they shortened the chemical bath from 50 days to about 12 days. Dr. Dilgeet Gill was surprised to discover that the cells had not turned into embryonic stem cells-but at the age of rejuvenation into skin cells that behaved as if they came from 23-.
He said, “I remember the day when the results came back. I didn’t believe that some cells were 30 years younger than I expected. It was a very exciting day!”
The IPS method increases the risk of cancer, so this technology cannot be immediately transferred to the clinic. However, Professor Reik found it possible to rejuvenate the cells and was convinced that his team could find an alternative, safer method.
“The long-term goal is to extend healthy life expectancy for humans, not life expectancy, so that people can grow older in healthier ways,” he said.
Professor Reik states that some of the first applications may be to develop medicines that rejuvenate the skin of older people with amputated or burned parts of the body as a way to speed healing. .. Researchers have demonstrated that this is possible in principle by demonstrating that rejuvenated skin cells move faster in wound-simulating experiments.
The next step is to see if the technology works in other tissues such as muscles, liver, and blood cells.
Professor Melanie Wellham, executive chairman of the Biotechnology and Bioscience Research Council, who partially funded the research that led to the dolly of sheep, told BBC News that the long-term clinical benefits of this technology are not far away. He said it might be. ..
“If similar approaches and new therapies can rejuvenate immune cells, it turns out to be less responsive as we get older. In the future, people’s responses to vaccination and infections May be able to improve your ability to fight. “
The big question is whether research efforts in this area will lead to methods of systemic regeneration, elixirs of youth, or anti-aging pills. Professor Reik said the idea was not completely accepted.
“This technique has been applied to genetically modified mice and has some signs of rejuvenation. One study showed signs of rejuvenated pancreas, which is interesting because it may address diabetes. is.”
However, Professor Robin Lovell-Badge of the Crick Institute in London believes that the scientific hurdle between Professor Reik’s laboratory results and the simplest clinical application is considerable. Also, I don’t think it would be an easy process to convert the rejuvenation process to other types of tissue or actually anti-aging pills.
“If you find another chemical that does the same thing, it’s good, but it can be just as bad. So it’s ambitious to find these chemicals easily and think they’re safer. ..
“It’s quite possible that other types of cells may require different conditions that may be difficult to control. And whether you can do it safely with your whole body is pure. It’s as far away as I think it’s speculation. “— BBC
https://saudigazette.com.sa/article/619160/TECHNOLOGY/Rejuvenation-of-womans-skin-could-tackle-diseases-of-aging?ref=rss&format=simple&link=link Women’s skin rejuvenation can tackle aging illnesses