There’s an opposed affiliation between calcium channel blocker (CCB) use and glaucoma, in line with a examine printed on-line Sept. 7 in JAMA Ophthalmology.
Alan Kastner, M.D., from Moorfields Eye Hospital Nationwide Well being Service Basis Belief and College School London, and colleagues examined the affiliation between systemic CCB use and glaucoma and associated traits in a population-based cross-sectional examine involving U.Okay. Biobank contributors with full knowledge for evaluation of glaucoma standing, intraocular stress (IOP), and optical coherence tomography-derived internal retinal layer thicknesses. Information had been included for 427,480 adults (median age, 58 years), together with 33,175 CCB customers (7.8 p.c).
The researchers discovered that use of CCBs, however not different antihypertensive brokers, was related to elevated odds of glaucoma after adjustment for key sociodemographic, medical, anthropometric, and way of life components (odds ratio, 1.39). CCB use was additionally related to thinner macular ganglion cell-inner plexiform layer and macular retinal nerve fiber layer thickness (−0.34 and −0.16 µm, respectively), however not with IOP.
“This cross-sectional examine provides additional assist to an opposed affiliation between CCB use and glaucoma, regardless of no obvious affiliation with IOP,” the authors write. “This warrants additional investigation to find out whether or not the associations are causal and to probe potential underlying organic mechanisms.”
A number of authors disclosed ties to the pharmaceutical business.
Alan Kastner et al, Calcium Channel Blocker Use and Related Glaucoma and Associated Traits Amongst UK Biobank Members, JAMA Ophthalmology (2023). DOI: 10.1001/jamaophthalmol.2023.3877
Paula Anne Newman-Casey et al, Energy of Public Funding in Curated Massive Well being Information, JAMA Ophthalmology (2023). DOI: 10.1001/jamaophthalmol.2023.4156
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Antagonistic affiliation recognized for calcium channel blocker use, glaucoma (2023, September 9)
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